NEJM复发和难治性多发性骨髓瘤的CAR
时间:2021-6-21来源:治疗方法 作者:佚名 点击:次
北京看荨麻疹的好医院 http://baidianfeng.39.net/a_zhiliao/210116/8595950.html
Abstract
Background:Idecabtagenevicleucel(ide-cel,alsocalledbb),aB-cellmaturationantigen-directedchimericantigenreceptor(CAR)T-celltherapy,hasshownclinicalactivitywithexpectedCART-celltoxiceffectsinpatientswithrelapsedandrefractorymultiplemyeloma.
Methods:Inthisphase2study,wesoughttoconfirmtheefficacyandsafetyofide-celinpatientswithrelapsedandrefractorymyeloma.Patientswithdiseaseafteratleastthreepreviousregimensincludingaproteasomeinhibitor,animmunomodulatoryagent,andananti-CD38antibodywereenrolled.Patientsreceivedide-celtargetdosesof×to×CAR-positive(CAR+)Tcells.Theprimaryendpointwasanoverallresponse(partialresponseorbetter);akeysecondaryendpointwasa
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